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Mifepristone (Mifeprex, RU-486) works by blocking progesterone, which is essential for a pregnancy to develop. This prevents the existing pregnancy from progressing.
Misoprostol is then taken 24–48 hours after mifepristone. Misoprostol causes cramping and bleeding which empties the uterus, similar to an early miscarriage.
A follow-up visit should be scheduled a week or two later to confirm the success of the pregnancy termination through either an ultrasound or a blood test.
Medication abortion successfully ends pregnancy in 99.6% of cases, with a 0.4% risk of major complications and a mortality rate of less than 0.001% (0.00064%).
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